International Research journal of Management Science and Technology

  ISSN 2250 - 1959 (online) ISSN 2348 - 9367 (Print) New DOI : 10.32804/IRJMST

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NUCLEAR RECEPTOR LXR AS A THERAPEUTIC TARGET IN CANCER

    3 Author(s):  POOJA AGARWAL, DR. JYOTI, DR. ABNISH KUMAR GAUTAM

Vol -  7, Issue- 8 ,         Page(s) : 16 - 24  (2016 ) DOI : https://doi.org/10.32804/IRJMST

Abstract

Cancer is known medically as a malignant neoplasm, is a broad group of various diseases, all involving unregulated cell growth. There are about 200 different known cancers in humans (Apfel et al. 1994), such as breast cancer, prostate cancer, lung cancer, liver cancer, colon cancer, pancreatic cancer etc. Nuclear receptors are transcription factors present within cells which is responsible for sensing small biologically active molecules such as lipids and steroid hormones. The liver X receptor (LXR) is a member of the nuclear receptor. It present in two form LXRα (NR1H3) and LXRβ (NR1H2).

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