Metals like zinc, iron and copper are essential micronutrients required for a wide range of physiological processes in all plant organs for the activities of various metal-dependent enzymes and proteins. However, they can also be toxic at elevated levels. Metals like arsenic, mercury, cadmium and lead are nonessential and potentially highly toxic. Once the cytosolic metal concentration in plant turns out of control, phytotoxicity of heavy metal inhibits transpiration and photosynthesis, disturbs carbohydrate metabolism, and drives the secondary stresses like nutrition stress and oxidative stress, which collectively affect the plant development and growth (Krämer & Clemens, 2005). Plants have developed a complex network of highly effective homeostatic mechanisms that serve to control the uptake, accumulation, trafficking, and detoxification of metals. Components of this network have been identified continuously, including metal transporters in charge of metal uptake and vacuolar transport; chelators involved in metal detoxification via buffering the cytosolic metal concentrations; and chaperones helping delivery and trafficking of metal ions (Clemens, 2001).