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CLENBUTEROL EFFECTS ON RAT GASTROCNEMIUS MUSCLE AFTER ORAL AND INTRAPERITONEAL ADMINISTRATION.
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Author(s):
DR. NIKHLESH THAKUR
Vol - 8, Issue- 2 ,
Page(s) : 384 - 392
(2017 )
DOI : https://doi.org/10.32804/IRJMST
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Abstract
β-adrenergic agonists are sympathomimetic substances which mimic normal innervation functions in skeletal muscles. It increases muscle mass in laboratory animals mainly from a selective hypertrophy of skeletal muscle. Histopathological changes in rat gastrocnemius muscle had been investigated under normal and drug induced stress conditions. Rats were divided into three groups i, e. (i) control group (ii) rats given 5mg/ kg body weight/day clenbuterol orally and (iii) rats given same dose of clenbuterol intraperitoneally. The effects of chronic 15 day regular administration of β- adrenoceptor agonist, clenbuterol and withdrawal effect for next 15 days were evaluated in young male (wistar) rats. This chronic treatment revealed maximum hypertrophy of muscle fibres in the sections during 7-15 days. Clumping of nuclei at sub sarcolemmal positions were noticed which was more prominent in the rats that were given drug orally.
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